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Keyword - Thiol protease (KW-0788)

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Proteolytic enzyme with a cysteine residue (Cys) in its active site. There are many families of thiol proteases. The most well known one is the papain family (C1 in MEROPS classification) which is known to exist in most eukaryotes.


  • Sulfhydryl protease
  • Thiol peptidase
  • Thiol proteinase


Molecular function


cysteine-type peptidase activity [ GO:0008234 ]


Thiol proteaseProteaseMolecular functionHydrolase

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