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Keyword - Signal-anchor (KW-0735)

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Broader

Definition

Single-pass transmembrane protein (type II, III, and IV) possessing a membrane-spanning domain which targets the protein to the ER membrane. Typical features of signal-anchors are the presence of positively charged residues on the amino terminal side followed by an apolar segment of approx. 20 residues. The amino-acid composition is not very different from typical signal sequences.

Category

Domain

Graphical

MembraneDomainTransmembraneCellular componentSignal-anchor
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