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Keyword - Integrin (KW-0401)


Protein of the integrin family of cell surface heterodimeric receptors that mediates dynamic cell-to-cell as well as cell-to-matrix adhesion. Integrins function as mechanochemical sensors and transducers able to change rapidly and reversibly their adhesive functions by modulating their ligand-binding affinity. Each subunit has a large N-terminal extracellular domain followed by a transmembrane domain and a short C-terminal cytoplasmic region. Some subclasses of integrins share a common beta chain while having different alpha chains.


Molecular function

Gene Ontology


integrin-mediated signaling pathway [ GO:0007229 ]


IntegrinMolecular function
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Main funding by: National Institutes of Health

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