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Keyword - Immunoglobulin V region (KW-0394)

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Protein encoded by a variable region gene (V gene / V segment). The variable region is the region of the immunoglobulin (Ig) which varies greatly in amino acid sequence among different immunoglobulins of the same class. Each immunoglobulin molecules is a tetramer of two identical light chains and two identical heavy chains linked by disulfide bonds. The light chain has one variable region (VL) and one constant region (CL) domain, whereas the heavy chain has one variable region (VH) and three or four constant region domains (CH1 to CH4). The V regions confer the antigenic specificity, and are associated with the antigen-binding site. Variable and constant regions are encoded by separated genes, called V genes and C genes respectively, which join during cell differentiation.




antigen binding [ GO:0003823 ]


Immunoglobulin domainImmunoglobulin V regionDomain
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