Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Keyword - Complement pathway (KW-0180)

Keywords navigation

BroaderNarrower

Definition

Pathway which activates the proteins of the complement system, a group of blood proteins of the globulin class involved in the lysis of foreign cells after they have been coated with antibody, and which also promote the removal of antibody-coated foreign particles by phagocytic cells. The pathway proceeds by a cascade reaction of successive binding and proteolytic cleavage of complement components. This pathway can be activated by either IgG or IgM binding to an antigen.

Synonyms

  • Classical complement pathway
  • Complement activation classical pathway

Category

Biological process

GOi

complement activation, classical pathway [ GO:0006958 ]

Graphical

Complement pathwayImmunityInnate immunityBiological process

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health