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Keyword - Aspartyl protease (KW-0064)

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Proteolytic enzyme with an aspartate residue (Asp) in its active site. There are many families of aspartyl proteases. The most well known one is the pepsin family (A1 in MEROPS classification) which is known to exist in vertebrates, fungi, plants, retroviruses and some plant viruses.


  • Acid protease
  • Aspartate protease
  • Aspartic protease
  • Aspartic proteinase
  • Aspartic-type endopeptidase
  • Aspartyl proteinase


Molecular function

Gene Ontology


aspartic-type endopeptidase activity [ GO:0004190 ]


Aspartyl proteaseProteaseMolecular functionHydrolase
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