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Keyword - Hypusine biosynthesis (KW-0386)


Protein involved in the synthesis of hypusine, an amino acid formed by the two posttranslational steps in the modification of a lysine: (i) deoxyhypusine synthase catalyzes the transfer of a 4-aminobutyl moiety from spermidine to a specific lysine residue to form a deoxyhypusine residue, N-epsilon-(4-aminobutyl)lysine, and (ii) deoxyhypusine hydroxylase catalyzes the hydroxylation of the deoxyhypusine residue to form hypusine (N-epsilon-(4-amino-2-hydroxybutyl)lysine).


  • Hypusine anabolism
  • Hypusine biosynthetic process
  • Hypusine formation
  • Hypusine synthesis


Biological process

Gene Ontology


peptidyl-lysine modification to peptidyl-hypusine [ GO:0008612 ]


Hypusine biosynthesisBiological process
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