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Keyword - DNA end degradation evasion by virus (KW-1256)

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Viral protein that inhibits or counteracts prokaryotic host helicase/nuclease proteins in order to escape the antiviral activity of the latter. When functioning in their exonuclease mode, helicase/nuclease proteins such as bacterial RecBCD or AddAB degrade any free DNA end as well as the linear dsDNA products resulting from restriction Type II cleavage. Any prokaryotic virus that exposes free dsDNA ends as part of its life cycle must find the means to evade destruction by these host enzymes. Prokaryotic viruses escape this host defense by expressing inhibitors or by protecting the ends of their linear genomes from digestion.


Biological process

Gene Ontology


DNA end degradation evasion by virus [ GO:0099016 ]


Host-virus interactionDNA end degradation evasion by virusBiological process
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