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Keyword - Inhibition of host DNA replication by virus (KW-1248)

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Viral protein that blocks host DNA replication without inhibiting host transcription or translation. Inhibiting host replication provides an advantage during the virus life cycle by reducing or eliminating competing host macromolecular synthesis. Bacteriophage N4 for example is known to shut off the host DNA replication while the host genome remains structurally intact. Bacteriophage lambda prevents host DNA replication initiation and Staphylococcus bacteriophages target the replicative DNA polymerase processivity clamp and the helicase.


Biological process

Gene Ontology


inhibition of host DNA replication by virus [ GO:0098673 ]


Inhibition of host DNA replication by virusModulation of host cell cycle by virusHost-virus interactionBiological process
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