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Keyword - Inhibition of host IKBKE by virus (KW-1224)

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Viral protein involved in the evasion of host innate defenses by inhibiting the IKBKE/IKK-epsilon kinase. Upon viral infection, the DDX58/RIG-I or IFIH1/MDA5 receptors recognize foreign material and transmit the signal to downstream components MAVS and IKBKE. In turn, the IKBKE kinase phosphorylates and activates IRF3 and/or IRF7. Once phosphorylated, IRF3 and IRF7 translocate into the nucleus to drive transcription of interferons. Several viruses including arenaviruses or ebola virus interact directly with and inhibit IKBKE/IKK-epsilon to prevent IRFs activation.


Biological process

Gene Ontology


suppression by virus of host IKBKE activity [ GO:0039724 ]


Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host IKBKE by virusInhibition of host RLR pathway by virusBiological process
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