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Keyword - Inhibition of host tapasin by virus (KW-1108)

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Broader

Definition

Viral protein involved in the evasion of host adaptive immune response by inhibiting the tapasin/TAPBP protein. tapasin/TAPBP is a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on host cell surface. Its helps the MHC class I molecules to remain in a peptide receptive state, avoiding irreversible denaturation. Several retroviruses and DNA viruses encode proteins interacting with tapasin/TAPBP and inhibiting its activity.

Category

Biological process

Gene Ontology

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GOi

suppression by virus of host tapasin activity [ GO:0039591 ]

Graphical

Host-virus interactionViral immunoevasionInhibition of host tapasin by virusInhibition of host adaptive immune response by virusBiological process
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