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Keyword - Inhibition of host STAT2 by virus (KW-1106)

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Viral protein involved in the evasion of type I and III interferon pathways by inhibiting STAT2 protein. Upon viral infection, STAT2 is activated by IFN-alpha/beta or IFN-lambda that bind to specific cell surface receptors. In turn, IFN-alpha/beta (or IFN-lambda) induces heterodimerization of STAT1 and STAT2 by phosphorylation, leading to STAT2 nuclear localization and subsequent induction of IFN-stimulated genes. Many viruses interfere with STAT2 activation, often by preventing STAT2 phosphorylation and nuclear localization.


Biological process

Gene Ontology


suppression by virus of host STAT2 activity [ GO:0039564 ]


Host-virus interactionInhibition of host STAT2 by virusInhibition of host innate immune response by virusViral immunoevasionInhibition of host interferon signaling pathway by virusBiological process
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