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Keyword - Inhibition of host RIG-I by virus (KW-1088)

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Broader

Definition

Viral protein involved in the evasion of host innate defense by inhibiting the DDX58/RIG-I protein. Upon recognition of viral RNA, the cytosolic receptor DDX58/RIG-I initiates an antiviral signaling cascade by interacting with downstream partners. Several viral proteins inhibit DDX58/RIG-I via direct interaction while others via proteolytic cleavage.

Category

Biological process

Gene Ontology

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GOi

suppression by virus of host RIG-I activity [ GO:0039540 ]

Graphical

Inhibition of host RIG-I by virusHost-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host RLR pathway by virusBiological process
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