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How are protein sequence variety and protein diversity represented in UniProtKB?

Last modified April 10, 2018

The article C. R. Biol. (2005) (2008 version) gives an overview on cellular processes that can lead to sequence variety and structural diversity in eukaryotes. It explains, with examples, how such processes are represented in UniProtKB.

This tutorial also shows how to use the UniProtKB annotation to extract specific datasets of entries, e.g.:

Remark: Most information in UniProtKB has one or several 'evidence tags' which describe the source of the information, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

Example of query:

Note: Examples on the website might differ slightly from those printed in the article, due to format changes and updates to the annotation.

Related terms: post-translational modification, posttranslational modification, PTM, alternative splicing, variant, isoform, mRNA editing, ribosomal frameshifting.

See also:

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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