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How is orthology established in UniProtKB/Swiss-Prot?

How is orthology established in UniProtKB/Swiss-Prot?

Information is combined from a variety of complementary sources to establish orthology relationships. Potential orthologs are initially identified using sequence similarity search programs such as BLAST. Orthology relationships are then verified manually using a combination of resources including scientific literature, sequence analysis tools, phylogenetic and comparative genomics databases such as Ensembl Compara, and other specialised databases such as species-specific collections.

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UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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