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UniProt key staff

Cecilia N. Arighi, Ph.D.
Team Lead, Curation (PIR)
Dr. Arighi joined the Protein Information Resource (PIR) as a biocurator in 2005 and was later appointed as a Research Assistant Professor of biochemistry and molecular & cellular biology at Georgetown University Medical Center. She is currently a Research Associate Professor at the Center for Bioinformatics and Computational Biology at the University of Delaware. Dr. Arighi is leader of the curation efforts at PIR, where she oversees expert entry curation and UniRule curation for automatic annotation. She is also involved in efforts to improve coverage and access to literature and annotations in UniProt entries via interaction with other databases, use of text mining and community crowdsourcing. She is involved in other projects synergistic with UniProt activities, such as Protein Ontology and BioCreative.

Lionel Breuza, Ph.D.
Head of Chordata Curation (SIB)
Dr. Breuza joined the Swiss-Prot group at the SIB Swiss Institute of Bioinformatics in 2004 where he worked as a Swiss-Prot database biocurator with a focus on vertebrate proteomes. Since 2009 he heads the chordata curation program at the SIB, managing a team of biocurators and organizing the curation work of vertebrate proteins and in particular of the human proteome.

Elisabeth Coudert, Ph.D.
Head of Transversal Curation (SIB)
Dr. Coudert joined the Swiss-Prot group at the SIB Swiss Institute of Bioinformatics in Geneva in 2000 where she worked as a biocurator in the Prokaryotic Protein Annotation Program. In 2008 she became responsible for this program. She is now the leader of a team whose members are involved in various projects including the development of the Rhea, ENZYME, SwissLipids and PROSITE resources, toxin biocuration, and taxonomy data management.

Hongzhan Huang, Ph.D.
Team Lead, Bioinformatics (PIR)
Dr. Huang joined the Protein Information Resource (PIR) in Washington in 1999 where he worked as senior bioinformatics scientist until his appointment in 2002 as Research Assistant Professor for biochemistry and molecular and cellular biology at the Georgetown University Medical Center (GUMC). In 2009, he was appointed as Research Associate Professor for computer and information sciences at the University of Delaware (UD). Dr. Huang is the bioinformatics team lead at PIR, and in the UniProt project he works on the development of bioinformatics infrastructure.

Damien Lieberherr, Ph.D.
Head of Plant Curation (SIB)
Dr. Lieberherr joined the Swiss-Prot group at the SIB Swiss Institute of Bioinformatics in Geneva in 2004 where he worked as a Swiss-Prot database biocurator with a focus on plant (Viridiplantae) proteomes. Since 2017 he heads the plant curation program at the SIB, managing a team of biocurators and organizing the curation work of plant proteins.

Michele Magrane, B.Sc. (Hons.)
Curation Coordinator (EMBL-EBI)
Michele Magrane joined EMBL-EBI in 1997 as a Swiss-Prot database curator and became Swiss-Prot curation coordinator in 2001. Since 2002, she has held the position of UniProt annotation coordinator within the Protein Function Content team at EMBL-EBI. She manages a team of biocurators who contribute to the expert curation of UniProtKB and is responsible for curator training, quality control and documentation. She was a founding member of the International Society for Biocuration and has served on the Nominating and Award Committees of the society.

Maria J. Martin, Ph.D.
Team Leader, Protein Function Development (EMBL-EBI)
Dr. Martin is the Protein Function Development Team Leader at the EMBL-European Bioinformatics Institute (EMBL-EBI) in Cambridge, UK. She is a world expert in the management of database resources with twenty years of experience in developing protein sequence resources at EMBL-EBI. Since joining EMBL-EBI in 1996, she has been involved in the strategic planning, data analysis and development of many database resources at this institute with special focus on protein data and leading the bioinformatics aspects of the Universal Protein Resource (UniProt), the world leading database of classified and functionally annotated protein sequences. In this role, she has extensive experience in developing database software and tools for UniProt and GO biocurators and researchers. Additionally, she leads the GO Annotation development team and the Enzyme portal resource. Her interests include the study of novel methods for protein annotation and representation, the provision of quality annotation Reference Proteomes for the scientific community, and data analysis and visualization of protein data in the context of other –omics data i.e. proteomics and variation. She is key staff of the UniProt Consortium and an active member of the GO and QfO Consortia. Dr. Martin has served on numerous scientific advisory committees, such as the SysKid consortium, a large-scale integrating European research project in kidney disease. She is the EMBL-EBI Scientific Lead for Open targets, a public-private partnership that uses human genetics and multi-omics data for systematic drug-target identification and prioritization. She has well-established working relationships with many groups in UK and Consortium members, and a broad network of contacts that include the NCBI in the USA, various sequencing centers and users specializing in a variety of biological domains.

Peter B. McGarvey, Ph.D.
Scientific Coordinator (PIR)
Dr. McGarvey is Deputy Director of the Innovation Center for Biomedical Informatics (ICBI) and Associate Professor in the Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center (GUMC). He is coordinator and a bioinformatics scientist for UniProt at PIR and is also involved in outreach and dissemination activities. Dr. McGarvey has academic and commercial experience in molecular biology, biotechnology, bioinformatics and software development, and his research interests include genomic and proteomic analysis, biological databases, and data visualization.

Darren Natale, Ph.D.
Team Lead, Protein Science (PIR)
Dr. Natale joined PIR in 2002. He ensures the validity of the relationships between proteins classified by sequence similarity. He is responsible for providing these protein classes with names and detailed functional, structural and evolutionary descriptions. The focus of Dr. Natale’s input in the UniProt project is, in part, the creation and curation of annotation rules governing the enhancement of information about uncharacterized proteins based on what is known about closely-related characterized proteins. He is a curator for both the UniProtKB and for Protein Ontology, and for each, he uses large-scale data mining coupled with manual oversight to make useful scientific inferences. He possesses over 18 years’ experience with protein comparison and classification, the lynchpin of annotation transfer.

Sandra E. Orchard, B.Sc.
Team Leader, Protein Function Content (EMBL-EBI)
In 2002 Sandra Orchard joined EMBL-EBI as a senior scientific database curator, working on UniProt KB, Gene Ontology, InterPro, IntAct, the Complex Portal and Enzyme Portal. She served as project manager for the Proteomics Standards Initiative and project leader of the Intact Molecular Interaction Database, was Proteomics Services Team Coordinator and later became Molecular Interactions Team Leader. In 2017, she became Protein Function Content Leader and thus is responsible for UniProt and Gene Ontology data curation at EMBL-EBI. Her team applies advanced methods for ensuring the accuracy and quality of UniProt, carrying out manual annotation and producing the rules for automated annotation.

Ivo Pedruzzi, Ph.D.
Head of Microbes Curation (SIB)
Dr. Pedruzzi joined the Swiss-Prot group at the SIB Swiss Institute of Bioinformatics in 2004 as a Swiss-Prot database biocurator for the fungal protein annotation program. He has subsequently been involved in Swiss-Prot’s automatic annotation effort HAMAP, manually curating annotation rules and maintaining and further developing the system. Since 2018 he is team leader of the newly formed microbial curation program, which encompasses the curation of proteins from prokaryotes, fungi and viruses, as well as automatic annotation of proteins of all domains of life via HAMAP.

Sylvain Poux, Ph.D.
Head of Quality Assurance (SIB)
Dr. Poux joined the Swiss-Prot group at the SIB Swiss Institute of Bioinformatics in Geneva in 2002. After working as biocurator and being involved in quality assurance and defining annotation rules, he became head of the Annotation and Integration Department of the Swiss-Prot group at SIB in 2009. Dr. Poux is now in charge of the quality assurance at SIB and oversees expert curation work before integration in UniProtKB/Swiss-Prot.

Manuela Pruess, Ph.D.
Project Coordinator (SIB)
Dr. Pruess joined EMBL-EBI in 2001 as Swiss-Prot curation coordinator and transitioned to the role of cooperation coordinator in 2004. In 2010, she moved to the SIB Swiss Institute of Bioinformatics in Geneva where she currently works as the UniProt project coordinator for SIB, following up on project development and coordinating progress reports and meetings for this site.

Shriya Raj, Ph.D.
Research Support Officer and Project Coordinator for UniProt (EMBL-EBI)
Dr. Raj joined EMBL-EBI as a Research Support Officer in 2018 and took over as UniProt project coordinator. In this role, she liaises with keystaff across all three sites, monitors the general project development, coordinates grant and progress report submissions, organises regular progress meetings as well as the UniProt Consortium and Scientific Advisory Board meetings.

Nicole Redaschi, Ph.D.
Head of Development (SIB)
Dr. Redaschi joined the European Bioinformatics Institute (EMBL-EBI) in 1996 as a database developer for the European Nucleotide Archive (ENA) and became head of database applications in 1998. She moved to the Swiss-Prot group at the SIB Swiss Institute of Bioinformatics in Geneva in 2002, where she became coordinator of database software development, and in 2009, the head of the software development department. She is responsible for the UniProt development at the SIB and the development of several SIB resources, including the PROSITE and HAMAP resources for protein classification and annotation, the ENZYME resource for enzyme nomenclature, the Rhea resource of biochemical reactions, and the ViralZone resource of viral biology, as well as various services of the ExPASy proteomics website.

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Main funding by: National Institutes of Health

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