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Binary interactions

Last modified May 11, 2020

This subsection of the 'Interaction section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the IntAct database. It is updated at every UniProt release.

For UniProtKB/Swiss-Prot entries that describe more than one protein (isoforms or/and products of proteolytic cleavage, i.e. CHAIN or PEPTIDE), each of these protein forms has its interactions listed in a separate block.

Interactions with the displayed protein, or with one of its isoforms or proteolytic products, are shown in tables of 3 columns:

  • The 'With' column reports the gene name and the UniProtKB accession number of the interacting protein. If the interaction partner is a specific isoform or a product of proteolytic cleavage, this information includes the isoform name and identifier, or the peptide/chain name and identifier. Interacting proteins may be derived from different species, e.g. due to the experimental design or reflecting a pathogen-host interaction. In such cases, the organism of the interacting protein is included.
    Example: Q8WUM4
  • The '#Exp' column indicates the number of experiments in the IntAct database which support the interaction.
  • The 'IntAct' column contains the IntAct database accession numbers of the two interacting proteins.

Homotypic interactions are indicated by the presence of the qualifier 'itself' in the 'With' column.
Example: P62258

Homotypic interactions are listed before heteromeric interactions, which are sorted alphanumerically based on their gene name.
Example: Q64279

UniProtKB 'Binary interactions' are automatically derived from the IntAct database, but represent only a subset of the binary interactions found in IntAct. The complete IntAct set can be accessed using the link in the 'Cross-references' section.
Example: P51617 (Protein-protein interaction databases)

More examples: P62258, Q8T4F7, P02829, O43521, Q07817

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Main funding by: National Institutes of Health

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