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Alex Bateman

Senior Team Leader Protein Sequence Resources and Group Leader Bateman Research Group.

E-mail: agbnull@ebi.nullac.uk

EMBL Outstation European Bioinformatics Institute (EMBL/EBI)
Wellcome Trust Genome Campus
Hinxton, Cambridge
CB10 1SD
United Kingdom
Phone: +44 (0)1223 379 494100
Fax: +44 (0)1223 494469

Short biography

Dr. Alex Bateman joined EMBL-EBI as the Head of Protein Sequence Resources cluster in 2012 and has oversight for world leading protein and ncRNA related databases, namely UniProt, Pfam, Rfam, RNAcentral and InterPro. He took over from Dr. Rolf Apweiler as the PI for the UniProt grant. In addition, the work of the Bateman Research Group focuses on the analysis of protein and RNA sequences and understanding how they evolve, function and interact. Prior to that he managed the production of numerous popular biological databases such as Pfam and Rfam at the Sanger Institute. He was formerly a member of, and Chairman of the ISB’s Executive Committee. He was also Executive Editor for Bioinformatics and Editor of Nucleic Acids Research’s database issue. He recently edited a book on protein families with Christine Orengo.

Groups

The Protein Sequence Resources cluster at the EMBL-EBI includes world-leading databases including UniProt, InterPro, Pfam and Rfam. In addition the work of the Bateman Research Group focuses on the analysis of protein and RNA sequences, to understand how they evolve, function and interact.

Selected publications

  1. Das D, Murzin AG, Rawlings ND, Finn RD, Coggill P, Bateman A, Godzik A, Aravind L: Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis. BMC Bioinformatics, 2014, 15: 75. doi: 10.1186/1471-2105-15-75.
  2. Finn RD, Bateman A, Clements J, Coggill P, Eberhardt RY, Eddy SR, Heger A, Hetherington K, Holm L, Mistry J, Sonnhammer EL, Tate J, Punta M: Pfam: the protein families database. Nucleic Acids Res. 2014, 42: D222-230. doi: 10.1093/nar/gkt1223.
  3. Finn RD, Miller BL, Clements J, Bateman A: iPfam: a database of protein family and domain interactions found in the Protein Data Bank. Nucleic Acids Res. 2014, 42: D364-373. doi: 10.1093/nar/gkt1210.
  4. Mitchell A, Chang HY, Daugherty L, Fraser M, Hunter S, Lopez R, McAnulla C, McMenamin C, Nuka G, Pesseat S, Sangrador-Vegas A, Scheremetjew M, Rato C, Yong SY, Bateman A, Punta M, Attwood TK, Sigrist CJ, Redaschi N, Rivoire C, Xenarios I, Kahn D, Guyot D, Bork P, Letunic I, Gough J, Oates M, Haft D, Huang H, Natale DA, Wu CH, Orengo C, Sillitoe I, Mi H, Thomas PD, Finn RD: The InterPro protein families database: the classification resource after 15 years. Nucleic Acids Res., 2014 Nov 26. pii: gku1243.
  5. Nawrocki EP, Burge SW, Bateman A, Daub J, Eberhardt RY, Eddy SR, Floden EW, Gardner PP, Jones TA, Tate J, Finn RD: Rfam 12.0: updates to the RNA families database. Nucleic Acids Res., 2014 Nov 11. pii: gku1063.
  6. Poux S, Magrane M, Arighi CN, Bridge A, O’Donovan C, Laiho K; UniProt Consortium: Expert curation in UniProtKB: a case study on dealing with conflicting and erroneous data. Database (Oxford), 2014, 2014: bau016. doi: 10.1093/database/bau016.
  7. Rawlings ND, Waller M, Barrett AJ, Bateman A: MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res. 2014, 42: D503-509. doi: 10.1093/nar/gkt953.
  8. Schreiber F, Patricio M, Muffato M, Pignatelli M, Bateman A: TreeFam v9: a new website, more species and orthology-on-the-fly. Nucleic Acids Res. 2014, 42: D922-925. doi: 10.1093/nar/gkt1055.
  9. UniProt Consortium Activities at the Universal Protein Resource (UniProt). Nucleic Acids Res. 2014, 42: D191-198. doi: 10.1093/nar/gkt1140.
  10. Burge SW, Daub J, Eberhardt R, Tate J, Barquist L, Nawrocki EP, Eddy SR, Gardner PP, Bateman A: Rfam 11.0: 10 years of RNA families. Nucleic Acids Res. 2013, 41: D226-232. doi: 10.1093/nar/gks1005.
  11. Eberhardt RY, Chang Y, Bateman A, Murzin AG, Axelrod HL, Hwang WC, Aravind L: Filling out the structural map of the NTF2-like superfamily. BMC Bioinformatics 2013, 14: 327. doi: 10.1186/1471-2105-14-327.
  12. Hwang WC, Bakolitsa C, Punta M, Coggill PC, Bateman A, Axelrod HL, Rawlings ND, Sedova M, Peterson S. Eberhardt RY, Aravind L, Pascual J, Godzik A: LUD, a new protein domain associated with lactatae utilization. BMC Bioinformatics 2013, 14:341. doi: 10.1186/1471-2105-14-341.
  13. Mistry J, Coggill P, Eberhardt RY, Deiana A, Giansanti A, Finn RD, Bateman A, Punta M: The challenge of increasing Pfam coverage of the human proteome. Database (Oxford) 2013, 2013:bat023. doi: 10.1093/database/bat023.
  14. Mistry J, Finn RD, Eddy SR, Bateman A, Punta M: Challenges in homology search: HMMER3 and convergent evolution of coiled-coil regions. Nucleic Acids Res. 2013, 41:e121. doi: 10.1093/nar/gkt263.
  15. Buljan M, Chalancon B, Eustermann S, Wagner GP, Fuxreiter M, Bateman A, Babu MM: Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networks. Mol. Cell, 2012, 46: 871-883.
  16. Buljan M, Frankish A, Bateman A: Quantifying the mechanisms of domain gain in animal protein. Genome Biol., 2010, 11: R74.
  17. Bateman A, Finn RD, Sims PJ, Wiedmer T, Biegert A, Soeding J: Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors. Bioinformatics, 2009, 25: 159-162.
  18. Schuster-Boeckler B, Bateman A: Protein interactions in human genetic diseases. Genome Biol., 2008, 9: R9.
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Main funding by: National Institutes of Health

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