---------------------------------------------------------------------------- UniProt - Swiss-Prot Protein Knowledgebase SIB Swiss Institute of Bioinformatics; Geneva, Switzerland European Bioinformatics Institute (EBI); Hinxton, United Kingdom Protein Information Resource (PIR); Washington DC, USA ---------------------------------------------------------------------------- Description: Blood group antigen proteins: list of entries Name: bloodgrp.txt Release: 2024_02 of 27-Mar-2024 ---------------------------------------------------------------------------- This file is a summary of the human proteins that are responsible for the molecular basis of the blood group antigens. Blood group antigens are surface markers on the outside of the red blood cell membrane. Most of them are proteins, but some are carbohydrates attached to lipids or proteins. A good source of information on blood group antigens can be found in: Reid M.E., Lomas-Francis C. The Blood Group Antigen FactsBook Academic Press, London / San Diego, (1997). Blood group antigen mutation database: https://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/home ____________ _______________________________________________________________ Blood Group Carrier or effector protein name system Gene name Swiss-Prot cross reference Antigen names ____________ _______________________________________________________________ ABO Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase (EC 2.4.1.40) (Histo-blood group A transferase) / Fucosylglycoprotein 3-alpha-galactosyltransferase (EC 2.4.1.37) (Histo-blood group B transferase). Gene: ABO BGAT_HUMAN (P16442) Antigens: A/B Chido/Rodgers Complement C4. Gene: C4A and C4B CO4A_HUMAN (P0C0L4) CO4B_HUMAN (P0C0L5) Antigens: Ch1 to Ch6, WH, Rg1, Rg2 Colton Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Water channel protein for red blood cells and kidney proximal tubule) (Urine water channel). Gene: AQP1; CHIP28 AQP1_HUMAN (P29972) Antigens: Co(a/b) Cromer Complement decay-accelerating factor (CD55 antigen). Gene: DAF; CD55 DAF_HUMAN (P08174) Antigens: Cr(a), Dr(a), Es(a), Tc(a/b/c), Wd(a), WES(a/b), IFC, UMC, GUTI Diego Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Solute carrier family 4 member 1) (CD233 antigen). Gene: SLC4A1; AE1; EPB3; DI B3AT_HUMAN (P02730) Antigens: Di(a/b), FR(a/a+), Wr(a/b), Wd(a), Rb(a), WARR, ELO, BOW, Wu, Vg(a), Bp(a), Hg(a), Mo(a), Sw(a), Tr(a) Dombrock Ecto-ADP-ribosyltransferase 4 (EC 2.4.2.31) (NAD(P)(+)-- arginine ADP-ribosyltransferase 4) (Mono(ADP-ribosyl) transferase 4) (Dombrock blood group carrier molecule) (CD97 antigen). Gene: ART4; D0; DOK1 NAR4_HUMAN (Q93070) Antigens: Do(a/b), Gy(a), Hy, Jo(A) Duffy Duffy antigen (Fy glycoprotein) (Glycoprotein D) (GpFy) (CD234 antigen). Gene: FY; GPD; DARC ACKR1_HUMAN (Q16570) Antigens: Fy(a/b) Gerbich Glycophorin-C (PAS-2') (Glycoprotein beta) (Glycoconnectin) (Sialoglycoprotein-D) (Glycophorin-D) (GpD). Gene: GYPC; GPC GLPC_HUMAN (P04921) Antigens: An(a), Dh(A), Ls(a), Wb GIL Aquaporin-3 (AQP-3). Gene: AQP3 AQP3_HUMAN (Q92482) Hh Galactoside 2-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)Ft 1) (Fucosyltransferase 1). Gene: FUT1 FUT1_HUMAN (P19526) Galactoside 2-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)Ft 2) (Fucosyltransferase 2) (Secretor factor). Gene: FUT2 FUT2_HUMAN (Q10981) Antigens: H/h, Se/se Indian CD44 antigen (Phagocytic glycoprotein I) (PGP-1) (Hutch-I) (Extracellular matrix receptor-III) (ECMR-III) (Hermes antigen) (Hyaluronate receptor) (Heparan sulfate proteoglycan) (Epican). Gene: CD44; LHR CD44_HUMAN (P16070) Antigens: In(a/b) John-Milton- Semaphorin-7A (Semaphorin-L) (Sema L) (Semaphorin-K1) Hargen (Sema K1) (CD108 antigen) (CDw108). Gene: SEMA7A; SEMAL; CD108 SEM7A_HUMAN (O75326) Kell Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen). Gene: KEL KELL_HUMAN (P23276) Antigens: K/k, Kp(a/b/c), Js(a/b), Ul(a), KEL11/17, KEL14/24 Kidd Urea transporter, erythrocyte. Gene: SLC14A1; HUT11; JK; RACH1; UT1; UTE UT1_HUMAN (Q13336) Antigens: Jk(a/b) Knops Complement receptor type 1 (C3b/C4b receptor) (CD35 antigen). Gene: CR1; C3BR CR1_HUMAN (P17927) Antigens: Kn(a/b), McC(a), Sl(a), Vl, Yk(a) Kx Membrane transport protein XK (Kx antigen). Gene: XK XK_HUMAN (P51811) Landsteiner- Intercellular adhesion molecule-4 (ICAM-4) Wiener (Landsteiner-Wiener blood group glycoprotein) (LW blood group protein) (CD242 antigen). Gene: ICAM4; LW ICAM4_HUMAN (Q14773) Antigens: LW(a/b) Lewis Galactoside 3(4)-L-fucosyltransferase (EC 2.4.1.65) (Fucosyltransferase 3) (FUCT-III). Gene: FUT3; LE FUT3_HUMAN (P21217) Antigens: Le(a/b) Lutheran Lutheran blood group glycoprotein (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen). Gene: BCAM; LU; MSK19 BCAM_HUMAN (P50895) Antigens: Lu(a/b), Au(a/b), LU6 to LU20 MNS Glycophorin-A (PAS-2) (Sialoglycoprotein alpha) (MN sialoglycoprotein) (CD235a antigen). Gene: GYPA; GPA GLPA_HUMAN (P02724) Glycophorin-B (PAS-3) (Sialoglycoprotein delta) (SS-active sialoglycoprotein) (CD235b anrigen). Gene: GYPB; GPB GLPB_HUMAN (P06028) Antigens: M/N, S/s, U, He, Mi(a), M(c), Vw, Mur, M(g), Vr, M(e), Mt(a), St(a), Ri(a), Cl(a), Ny(a), Hut, Hil, M(v), Far, Mit, Dantu, Hop, Nob, En(a), ENKT, etc. OK Basigin (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen). Gene: BSG BASI_HUMAN (P35613) Antigen: Ok P UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3- GalTase 3) (Beta3Gal-T3) (b3Gal-T3) (Galactosylgalactosylglucosylceramide beta-D-acetyl- galactosaminyltransferase) (Globoside synthase). Gene: B3GALN1; B3GALT3 B3GL1_HUMAN (O75752) Antigens: P1 RAPH CD151 antigen (Platelet-endothelial tetraspan antigen 3) (PETA-3) (GP27) (Membrane glycoprotein SFA-1) (Tetraspanin-24) (Tspan-24). Gene: CD151; TSPAN24 CD151_HUMAN (P48509) Antigens: MER2 Rh Blood group RH(CE) polypeptide (Rhesus C/E antigens) (RHPI) (CD240CE antigen). Gene: RHCE; RHC; RHE RHCE_HUMAN (P18577) Blood group RH(D) polypeptide (Rhesus D antigen) (RHPII) (CD240D antigen). Gene: RHD RHD_HUMAN (Q02161) Antigens: C/c, E/e, D, f, C(e), C(w), C(x), V, E(w), G, Tar, VS, D(w), cE, etc. Scianna/ Erythroid membrane-associated protein (hERMAP) (Scianna Radin blood group antigen) (Radin blood group antigen). Gene: ERMAP; RD; SC ERMAP_HUMAN (Q96PL5) Antigens: Sc(1/2), Sc3, Sc4/Rd, Sc5/STAR, Sc6/SCER, Sc7/SCAN Vel Small integral membrane protein 1 (Vel blood group antigen). Gene: SMIM1 SMIM1_HUMAN (B2RUZ4) Antigens: Vel Xg Glycoprotein Xg (Protein PBDX). Gene: XG; PBDX XG_HUMAN (P55808) Antigens: Xg(a) Yt Acetylcholinesterase (EC 3.1.1.7) (AChE). Gene: ACHE ACES_HUMAN (P22303) Antigens: Yt(a/b) ----------------------------------------------------------------------- Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License -----------------------------------------------------------------------