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Definition

An autosomal recessive malodor condition characterized by extraoral blood-borne halitosis resulting from the accumulation of sulfur-containing metabolites. In extraoral blood-borne halitosis, malodorant compounds are carried to the lungs, where they enter the breath. Affected individuals have a cabbage-like breath odor, high levels of methanethiol and dimethylsulfide in oral and nasal breath, and elevated urinary excretion of dimethylsulfoxide in the absence of intake of dimethylsulfide-containing food or use of sulfur-containing medication, lower-gastrointestinal problems, and known metabolic defects, such as methionine adenosyltransferase deficiency and tyrosinemia.

Acronym

EHMTO

Synonyms

Extraoral halitosis due to MTO deficiency
Extraoral halitosis with dimethylsulfoxiduria
Methanethiol oxidase deficiency
MTO deficiency

 
Disclaimer

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Main funding by: National Institutes of Health

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