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Definition

A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN8 patients manifest congenital insensitivity to pain resulting in ulceration to the fingers, tongue, lips, and other distal appendages. Some patients may also have decreased sweating and tear production.

Acronym

HSAN8

Synonyms

Hereditary sensory and autonomic neuropathy type VIII
HSAN VIII

Keywords

Neurodegeneration
Neuropathy

 
Disclaimer

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