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Definition

An autosomal dominant disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of Cushing syndrome typical signs. Clinical features include hypoglycemia, hypertension, metabolic alkalosis, chronic fatigue and profound anxiety.

Acronym

GCCR

Synonyms

Chrousos syndrome
Cortisol resistance from glucocorticoid receptor defect
GCCR deficiency
GCR deficiency
Glucocorticoid receptor deficiency
GRL deficiency

 
Disclaimer

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