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Definition

A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN7 is characterized by congenital inability to experience pain resulting in self-mutilations, slow-healing wounds, and multiple painless fractures. mild muscle weakness, delayed motor development, slightly reduced motor and sensory nerve conduction velocities, hyperhidrosis and gastrointestinal dysfunction.

Acronym

HSAN7

Synonyms

Congenital insensitivity to pain with gastrointestinal dysfunction and hyperhidrosis
Hereditary sensory and autonomic neuropathy type VII
HSAN VII

Keywords

Neurodegeneration
Neuropathy

 
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