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Definition

A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. SPG52 is characterized by neonatal hypotonia that progresses to hypertonia and spasticity, and severe mental retardation with poor or absent speech development. Some patients may have seizures.

Acronym

SPG52

Synonyms

Cerebral palsy, spastic quadriplegic 6
CPSQ6

Keywords

Hereditary spastic paraplegia

 
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