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Definition

A form of dementia characterized by pathologic finding of frontotemporal lobar degeneration, presenile dementia with behavioral changes, deterioration of cognitive capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In most cases, protein tau deposits are found in glial cells and/or neurons.

Acronym

FTD

Synonyms

DDPAC
Disinhibition-dementia-parkinsonism-amyotrophy complex
FLDEM
Frontotemporal dementia-amyotrophic lateral sclerosis
Frontotemporal dementia and parkinsonism linked to chromosome 17
Frontotemporal dementia with parkinsonism
Frontotemporal lobar degeneration
Frontotemporal lobar degeneration with TAU inclusions
Frontotemporal lobe dementia
FTD-ALS
FTDP17
FTLD
FTLD with TAU inclusions
MSTD
Multiple system tauopathy with presenile dementia
Pallidopontonigral degeneration
Pick complex
PPND
Wilhelmsen-Lynch disease
WLD

Keywords

Neurodegeneration

 
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