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Definition

A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis.

Acronym

C3D

Synonyms

C3 deficiency autosomal recessive
Complement component 3 deficiency autosomal recessive

 
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