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Definition

An autosomal recessive metabolic condition characterized by increased sensitivity to certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium. BCHED results in slower hydrolysis of these drugs and, consequently, a prolonged neuromuscular block, leading to apnea. The duration of the prolonged apnea varies significantly depending on the extent of the enzyme deficiency.

Acronym

BCHED

Synonyms

Acholinesterasemia
Fluoride-resistant butyrylcholinesterase deficiency Japanese type
Fluoride-resistant hypocholinesterasemia Japanese type
Postanesthetic apnea
Pseudocholinesterase deficiency
Suxamethonium sensitivity

 
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