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Definition

A rare disease characterized by the combination of chronic mucocutaneous candidiasis, hypoparathyroidism and Addison disease. Symptoms of mucocutaneous candidiasis manifest first, followed by hypotension or fatigue occurring as a result of Addison disease. APS1 is associated with other autoimmune disorders including diabetes mellitus, vitiligo, alopecia, hepatitis, pernicious anemia and primary hypothyroidism.

Acronym

APS1

Synonyms

APECED
APS-1
Autoimmune polyendocrine syndrome type I
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
Autoimmune polyendocrinopathy syndrome type I
Autosomal dominant autoimmune polyendocrinopathy syndrome type I
Hypoadrenocorticism with hypoparathyroidism and superficial moniliasis
PGA I
Polyglandular autoimmune syndrome type I
Polyglandular deficiency syndrome Persian-Jewish type
Whitaker syndrome

 
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