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Definition

A classical lissencephaly. It is characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. The cortex is abnormally thick and poorly organized with 4 primitive layers. Associated with enlarged and dysmorphic ventricles and often hypoplasia of the corpus callosum.

Acronym

LIS1

Synonyms

Classic lissencephaly
Lissencephaly-1

Keywords

Lissencephaly

 
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