Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.


A X-linked recessive disorder of the central nervous system in which myelin is not formed properly. Clinically characterized by nystagmus, spastic quadriplegia, ataxia, and developmental delay.




Brain sclerosis diffuse familial
Pelizaeus-Merzbacher brain sclerosis
Pelizaeus-Merzbacher disease
Sudanophilic leukodystrophy Paelizeus-Merzbacher type




Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again