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Definition

A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN2A is an autosomal recessive disorder characterized by impairment of pain, temperature and touch sensation, onset of symptoms in infancy or early childhood, occurrence of distal extremity pathologies (paronychia, whitlows, ulcers, and Charcot joints), frequent amputations, sensory loss that affects all modalities of sensation (lower and upper limbs and perhaps the trunk as well), absence or diminution of tendon reflexes (usually in all limbs), minimal autonomic dysfunction, absence of sensory nerve action potentials, and virtual absence of myelinated fibers with decreased numbers of unmyelinated fibers in sural nerves.

Acronym

HSAN2A

Synonyms

Acroosteolysis Giaccai type
Congenital sensory neuropathy
Hereditary sensory and autonomic neuropathy type IIA
Hereditary sensory neuropathy type IIA
Hereditary sensory radicular neuropathy autosomal recessive
HSAN IIA
HSN2A
HSN IIA
Morvan disease
Neurogenic acroosteolysis
Progressive sensory neuropathy of children

Keywords

Neurodegeneration
Neuropathy

 
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