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Cloning of a novel membrane-linked metalloproteinase from human myeloma cells.

McKie N., Dallas D.J., Edwards T., Apperley J.F., Russell R.G.G., Croucher P.I.

We have isolated a novel cDNA from human myeloma cells encoding a member of the reprolysin family of metalloproteinases. Derived amino acid sequence predicts a protein of approx. 76 kDa. The open reading frame predicts the presence of a leader peptide, a pro-peptide with a 'cysteine switch', a metalloproteinase domain, a disintegrin-like domain, a cysteine-rich domain, an epidermal growth factor-like domain and a putative transmembrane sequence. Expression of the mRNA for this metalloproteinase has been demonstrated in human myeloma cells.

Biochem. J. 318:459-462(1996) [PubMed] [Europe PMC]

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