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A mouse TGF-beta type I receptor that requires type II receptor for ligand binding.

Suzuki A., Shioda N., Maeda T., Tada M., Ueno N.

A cDNA for a serine/threonine kinase receptor was isolated from a mouse brain cDNA library. The receptor transiently expressed on COS cells bound TGF-beta 1 not by itself but only when TGF-beta type II receptor was coexpressed. The molecular mass of the ligand-receptor complex was estimated to be 75 kDa. The type II receptor-dependent binding and the molecular mass of the complex suggest that the receptor is a TGF-beta type I receptor.

Biochem. Biophys. Res. Commun. 198:1063-1069(1994) [PubMed] [Europe PMC]

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