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Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.

Poltoratsky V.P., Shi X., York J.D., Lieber M.R., Carter T.H.

DNA-activated protein kinase (DNA-PK) is a serine/threonine protein kinase that interacts with a DNA end-binding heterodimeric protein, Ku, and is activated by double-stranded DNA. Genomic clones that contain the DNA-PK gene complement the murine scid defect, indicating that DNA-PK affects double-strand break repair and V(D)J recombination. Here we describe the cDNA sequence of the region that corresponds to about 100 kDa of C-terminal sequence of this large (> p350 kDa) protein. This region contains a kinase domain that has strong homology to phosphatidylinositol kinases.

J. Immunol. 155:4529-4533(1995) [PubMed] [Europe PMC]

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