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Characterization of an activated human ros gene.

Birchmeier C., Birnbaum D., Waitches G., Fasano O., Wigler M.

A human oncogene, mcf3, previously detected by a combination of DNA-mediated gene transfer and a tumorigenicity assay, derives from a human homology of the avian v-ros oncogene. Both v-ros and mcf3 can encode a protein with homology to tyrosine-specific protein kinases, and both mcf3 and v-ros encode a potential transmembrane domain N terminal to the kinase domain. mcf3 probably arose during gene transfer from a normal human ros gene by the loss of a putative extracellular domain. There do not appear to be any other gross rearrangements in the structure of mcf3.

Mol. Cell. Biol. 6:3109-3116(1986) [PubMed] [Europe PMC]

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