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Mass spectrometry analysis and biological characterization of the predatory ant Odontomachus monticola venom and venom sac components.

Tani N., Kazuma K., Ohtsuka Y., Shigeri Y., Masuko K., Konno K., Inagaki H.

We previously identified 92 toxin-like peptides and proteins, including pilosulin-like peptides 1⁻6 from the predatory ant Odontomachus monticola, by transcriptome analysis. Here, to further characterize venom components, we analyzed the venom and venom sac extract by ESI-MS/MS with or without trypsin digestion and reducing agent. As the low-molecular-mass components, we found amino acids (leucine/isoleucine, phenylalanine, and tryptophan) and biogenic amines (histamine and tyramine) in the venom and venom sac extract. As the higher molecular mass components, we found peptides and proteins such as pilosulin-like peptides, phospholipase A₂s, hyaluronidase, venom dipeptidyl peptidases, conotoxin-like peptide, and icarapin-like peptide. In addition to pilosulin-like peptides 1⁻6, we found three novel pilosulin-like peptides that were overlooked by transcriptome analysis. Moreover, pilosulin-like peptides 1⁻6 were chemically synthesized, and some of them displayed antimicrobial, hemolytic, and histamine-releasing activities.

Toxins 11:0-0(2019) [PubMed] [Europe PMC]

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