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The nucleotide sequence of a mouse renin-encoding gene, Ren-1d, and its upstream region.

Burt D.W., Mullins L.J., George H., Smith G., Brooks J., Pioli D., Brammar W.J.

The renin-encoding genes have been cloned from high (Ren-1d, Ren-2d)- and low (Ren-1c)-renin-producing strains of mice (DBA/2J and C57BL/10). Each of the genes is approx. 9.6 kb in length and consists of nine exons and eight introns. The entire nucleotide sequence of the Ren-1d gene has been determined and the 5'-flanking regions of the three genes, Ren-1c, Ren-1d and Ren-2d, have been compared. The significance of several potential regulatory signals found in the DNA is discussed.

Gene 84:91-104(1989) [PubMed] [Europe PMC]

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