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Establishment and Dysfunction of the Blood-Brain Barrier.

Zhao Z., Nelson A.R., Betsholtz C., Zlokovic B.V.

Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease.

Cell 163:1064-1078(2015) [PubMed] [Europe PMC]

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