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Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family.

Itoh N., Yonehara S., Schreurs J., Gorman D.M., Maruyama K., Ishii A., Yahara I., Arai K., Miyajima A.

Interleukin-3 (IL-3) binds to its receptor with high and low affinities, induces tyrosine phosphorylation, and promotes the proliferation and differentiation of hematopoietic cells. A binding component of the IL-3 receptor was cloned. Fibroblasts transfected with the complementary DNA bound IL-3 with a low affinity [dissociation constant (Kd) of 17.9 +/-3.6 nM]. No consensus sequence for a tyrosine kinase was present in the cytoplasmic domain. Thus, additional components are required for a functional high affinity IL-3 receptor. A sequence comparison of the IL-3 receptor with other cytokine receptors (erythropoietin, IL-4, IL-6, and the beta chain IL-2 receptor) revealed a common motif of a distinct receptor gene family.

Science 247:324-327(1990) [PubMed] [Europe PMC]

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