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SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice.

Nakamura Y., Ogura M., Ogura K., Tanaka D., Inagaki N.

We identified urate oxidase (UOX) as a target of SIRT5 by comparing mitochondrial proteins in livers of SIRT5-overexpressing transgenic (SIRT5 Tg) and wild-type mice by using two-dimensional electrophoresis. Acetylation levels of UOX in liver of SIRT5 Tg mice were approximately half of those in wild-type mice, and UOX activity was significantly increased. Invitro-synthesized UOX protein was acetylated when incubated with mitochondria from wild-type mice liver but the levels were less when incubated with those from SIRT5 Tg mice liver. These results suggest that SIRT5 activates UOX through deacetylation in mouse liver mitochondria.

FEBS Lett. 586:4076-4081(2012) [PubMed] [Europe PMC]

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