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Radioprotection by short-term oxidative preconditioning: role of manganese superoxide dismutase.

Belikova N.A., Glumac A., Rafikov R., Jiang J., Greenberger J.S., Kagan V.E., Bayir H.

Manganese superoxide dismutase (MnSOD) is vital to the protection of mitochondria and cells against oxidative stress. Earlier, we demonstrated that catalytically active homo-tetramer of MnSOD can be stabilized by oxidative cross-linking. Here we report that this effect may be translated into increased radioresistance of mouse embryonic cells (MECs) by pre-exposure to oxidative stress. Pre-treatment of MECs with antimycin A, rotenone or H(2)O(2) increased their survival after irradiation. Using MnSOD siRNA, we show that MECs with decreased MnSOD levels displayed a lowered ability to preconditioning. Thus oxidative preconditioning may be used for targeted regulation of MnSOD.

FEBS Lett. 583:3437-3442(2009) [PubMed] [Europe PMC]

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