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A new mRNA splice variant coding for the human EP3-I receptor isoform.

Kotelevets L., Foudi N., Louedec L., Couvelard A., Chastre E., Norel X.

The cellular localization of prostaglandin E2 receptors (EP) and their corresponding transcripts were investigated in human gastric and vascular tissues. A strong staining of the EP3 receptor on the gastric glands, mucous cells, media of the mammary and pulmonary arteries was observed by immunohistochemistry. We identified a new mRNA splice variant of the EP3 gene in human gastric fundic mucosa, mammary artery and pulmonary vessels. This EP3-Ic transcript contains exons 1, 2, 3, 5 and 6 of the EP3 gene and should be translated in the EP3-I isoform. In addition, the EP3-Ib, EP3-II, EP3-III, EP3-IV and EP3-e mRNAs were detected in these tissues.

Prostaglandins Leukot. Essent. Fatty Acids 77:195-201(2007) [PubMed] [Europe PMC]

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