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Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen.

Yamada S., Uchimura E., Ueda T., Nomura T., Fujita S., Matsumoto K., Funeriu D.P., Miyake M., Miyake J.

Using RNA interference (RNAi) to suppress gene expression, we attempted to identify tyrosine kinases involved in the extension of neurites from SH-SY5Y cells. A comprehensive analysis of gene "knock-down" profiles with small interfering RNAs (siRNAs) revealed candidate proteins that might control neurite extension. Phenotype-based screening of differentiating SH-SY5Y cells following retinoic acid (RA) stimulation indicated that twinfilin-2 is a protein that is involved in neurite outgrowth, as confirmed by morphological analysis of twinfilin-2-overexpressing cells.

Biochem. Biophys. Res. Commun. 363:926-930(2007) [PubMed] [Europe PMC]

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