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Identification and characterisation of a novel splice variant of the human CB1 receptor.

Ryberg E., Vu H.K., Larsson N., Groblewski T., Hjorth S., Elebring T., Sjoegren S., Greasley P.J.

Cannabinoid ligands are implicated in many physiological processes and to date two receptors have been identified. However, a growing body of evidence exists that suggests the presence of additional receptors. Whilst cloning the previously described hCB1a, we have identified a novel variant that we call hCB1b. Characterising these two splice variants demonstrates that they have a unique pharmacological profile and that their RNA's are expressed at low levels in a variety of tissues.

FEBS Lett. 579:259-264(2005) [PubMed] [Europe PMC]

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