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Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter.

Sun W., McPherson J.D., Hoang D.Q., Wasmuth J.J., Evans G.A., Montal M.

Degenerate DNA oligomers coding for highly conserved regions of the voltage-gated calcium channel were synthesized for the polymerase chain reaction (PCR) using DNA from a human brain cDNA library as template. PCR amplified a 640-bp DNA fragment from the human brain cDNA library. Sequencing revealed that this fragment encodes part of a protein highly homologous to a subtype of the dihydropyridine-sensitive calcium channel cloned from rabbit heart and rat brain. Southern analysis of panels of somatic cell hybrids mapped the 640-bp fragment, CACNL1A1, to human chromosome 12p13-pter.

Genomics 14:1092-1094(1992) [PubMed] [Europe PMC]

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