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Lack of association between suicide attempt and a polymorphism at the dopamine receptor D4 locus.

Persson M.L., Geijer T., Wasserman D., Rockah R., Frisch A., Michaelovsky E., Jonsson E.G., Apter A., Weizman A.

Dopaminergic neurotransmission has been implicated in suicidal behaviour. The 48 bp-repeat polymorphism in the gene coding for dopamine receptor D4 was investigated in a sample of suicide attempters (n = 165) and healthy control subjects (n = 99). No association between suicide attempts and this polymorphism was observed. Neither did any significant differences emerge in comparison with control subjects when the suicide attempters were grouped into different diagnostic categories: unipolar (n = 45), anxiety (n = 23), adjustment (n = 37) and personality disorders, cluster B (n = 36). The results suggest that alleles defined by the investigated polymorphism do not have a major impact on suicidal behaviour.

Psychiatr Genet 9:97-100(1999) [PubMed] [Europe PMC]

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