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Animal toxin annotation project

Statistics

UniProt release 2018_07 of Jul-18, 2018 contains 557,992 reviewed entries.

Total number of reviewed animal toxin entries: 5,926 .

Total number of reviewed venom protein entries: 6,367 .

Common name Scientific name Toxins Proteins
found in
venom
Species
producing
toxins
Species
secreting
venom
Snakes Serpentes 1,941 2,289 183 187
Spiders Araneae 1,414 1,488 114 114
Snails Gastropoda 1,220 1,232 107 105
Scorpions Scorpiones 786 971 69 75
Sea anemones Actiniaria 246 0 45 0
Insects Hexapoda 76 265 35 78
Lizards Anguimorpha 34 37 6 6
Fishes Teleostei 29 15 10 5
Scolopendra Scolopendridae 52 54 2 3
Mammals Mammalia 7 6 2 1
Hydra Hydroida 4 0 2 0
Toad Amphibia 76 3 16 2
Mites Acari 3 0 2 0
Starfishes Asteroidea 3 3 1 1
Worms Cerebratulus 3 0 1 0
Medusae Rhopilema 1 0 1 0
Jellyfishes Cubozoa 5 0 4 0
other metazoans - 26 4 12 2
All animals Metazoa 5,926 6,367 612 579

Venom protein targets in UniProtKB/Swiss-Prot distributed by taxonomical group. The idea for the table originates from the nomenclature proposition made by King et al. 2008 (PMID:18619481). The table proposed in this paper has been completed and links between venom proteins and targets have been added. Since this table may also help in nomenclature discussions, the descriptors (Greek letter that specifies the biological function) proposed by these authors are also indicated (see 2nd column). Note that multiple descriptors used for sodium channels are due to different modes of action on this channel. The targets are firstly ordered by types: ion channels, receptors (7TM and 1TM) and transporters, and secondly by abundance.

target: ion channel (voltage-gated and transmitter-gated) descriptor snake scorpion spider cone snail insect sea anemone all
voltage-gated sodium (Nav) channel beta, delta, iota, mu 2 362 182 96 3 91 740
potassium channel inhibitor (Includes the following 4 channels: KIR, K2P, Kv and KCa as targets) - 52 299 105 41 6 71 603
- voltage-gated potassium (Kv) channel kappa 46 194 92 23 0 67 437
- calcium-activated potassium (KCa) channel lambda 11 47 7 0 3 0 68
- inward-rectifier potassium (KIR) channel eta 0 0 0 0 1 0 1
- two-pore domain potassium (K2P) channel theta 0 0 0 0 0 0 0
nicotinic acetylcholine receptor alpha, psi 277 0 0 154 0 0 431
calcium channel inhibitor (Includes CaV and Ryr) - 55 25 133 83 7 0 320
- voltage-gated calcium (Cav) channel omega 11 3 124 77 6 0 225
- ryanodine receptor (RyR) phi 8 19 0 0 0 0 28
- P2RX receptor omicron 0 0 2 0 0 0 2
chloride channel inhibitor (Includes CLCN, CFTR and GABA(A) as targets) - 2 18 0 0 0 0 20
- voltage-gated chloride channels (CLCN) epsilon 0 18 0 0 0 0 18
- CFTR channel LAMBDA - in upper case 0 1 0 0 0 0 1
- GABA(A) receptor SIGMA - in upper case 0 0 0 0 0 0 0
glutamate receptor GAMMA - in upper case 0 0 11 19 0 0 30
HCNa nonspecific cation channel gamma 0 0 0 7 0 0 7
cyclic nucleotide-gated channel zeta 10 0 0 0 0 0 10
transient receptor potential (TRP) channel tau 0 1 4 0 0 4 20
acid-sensing ion (ASICs) channel pi 0 0 0 0 0 1 1
5-HT receptor sigma 0 0 0 1 0 0 1
target: receptor 7TM descriptor snake scorpion spider cone snail insect sea anemone all
muscarinic acetylcholine receptor - 27 0 0 0 0 0 27
adrenoceptor rho 13 12 0 1 0 0 27
bradykinin receptor - 6 2 5 0 10 0 92
dopamine receptor - 1 0 0 0 0 0 1
vasopressin/oxytocin receptor upsilon 0 0 0 4 0 0 4
endothelin receptor xi 6 0 0 0 0 0 6
vasoactive intestinal polypeptide receptor - 0 0 0 0 0 0 4
glucagon-like peptide receptor - 0 0 0 0 0 0 3
somatostatin receptor - 0 0 0 2 0 0 2
cholecystokinin receptor - 0 0 0 0 0 0 1
neurotensin receptor nu 0 0 0 3 0 0 3
target: receptor 1TM descriptor snake scorpion spider cone snail insect sea anemone all
vascular endothelial growth factor receptor - 16 0 0 0 0 0 16
epidermal growth factor receptor OMEGA - in upper case 0 0 0 0 0 4 4
target: transporter descriptor snake scorpion spider cone snail insect sea anemone all
noradrenaline transporter chi 0 0 0 9 0 0 9
glutamate transporter - 0 0 1 0 0 0 1

Snake venom proteins - 2,289 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 68.1%
at transcript level 24.1%
inferred from homology 7.8%
predicted N/A
uncertain N/A

Annotation categories Entries with Number of annotations Coverage
PubMed citations 2,289 1,879 unique 100%
General annotation 2,289 11,129 100%
Function 2,199 2,343 96.1%
Catalytic activity 515 517 22.5%
Subcellular location 0 0 N/A
Toxic dose 0 0 N/A
Sequence annotation 2,284 25,342 99.8%
Amino acid modifications 2,078 11,624 90.8%
Cross-references 2,289 0 100%
EMBL 1,366 0 59.7%
InterPro 1,994 0 87.1%
PDB 248 0 10.8%

100% of reviewed snake venom proteins entries are annotated with at least one keyword .

100% of reviewed snake venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Snail venom proteins - 1,232 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 39.4%
at transcript level 49.1%
inferred from homology 11.3%
predicted N/A
uncertain 0.2%

Annotation categories Entries with Number of annotations Coverage
PubMed citations 1,232 489 unique 100%
General annotation 1,232 5,399 100%
Function 588 599 47.7%
Catalytic activity 4 4 0.3%
Subcellular location 0 0 N/A
Toxic dose 0 0 N/A
Sequence annotation 1,217 8,069 98.8%
Amino acid modifications 1,111 4,087 90.2%
Cross-references 1,220 0 100%
EMBL 761 0 61.8%
InterPro 784 0 63.6%
PDB 82 0 6.7%
Conoserver 865 0 70.2%

100% of reviewed snail venom proteins entries are annotated with at least one keyword .

97.9% of reviewed snail venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Scorpion venom proteins - 971 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 60.5%
at transcript level 26%
inferred from homology 13.6%
predicted N/A
uncertain N/A

Annotation categories Entries with Number of annotations Coverage
PubMed citations 971 683 unique 100%
General annotation 971 3,827 100%
Function 860 895 88.6%
Catalytic activity 16 16 1.6%
Subcellular location 0 0 N/A
Toxic dose 0 0 N/A
Sequence annotation 966 5,942 99.5%
Amino acid modifications 797 2,878 82.1%
Cross-references 971 0 100%
EMBL 520 0 53.6%
InterPro 714 0 73.5%
PDB 100 0 10.3%

100% of reviewed scorpion venom proteins entries are annotated with at least one keyword .

100% of reviewed scorpion venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Spider venom proteins - 1,488 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 45%
at transcript level 48.8%
inferred from homology 6.2%
predicted N/A
uncertain N/A

Annotation categories Entries with Number of annotations Coverage
PubMed citations 1,488 446 unique 100%
General annotation 1,488 6,731 100%
Function 1,191 1,197 80%
Catalytic activity 217 217 14.6%
Subcellular location 0 0 N/A
Toxic dose 0 0 N/A
Sequence annotation 1,478 9,951 99.3%
Amino acid modifications 1,284 4,225 86.3%
Cross-references 1,488 0 100%
EMBL 1,045 0 70.2%
InterPro 1,164 0 78.2%
PDB 77 0 5.2%
ArachnoServer 1,140 0 76.6%

100% of reviewed spider venom proteins entries are annotated with at least one keyword .

100% of reviewed spider venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

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