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Animal toxin annotation project

Statistics

UniProt release 2022_01 of Feb-23, 2022 contains 566,996 reviewed entries.

Total number of reviewed animal toxin entries: 6,580 .

Total number of reviewed venom protein entries: 7,049 .

Common name Scientific name Toxins Proteins
found in
venom
Species
producing
toxins
Species
secreting
venom
Snakes Serpentes 2,009 2,356 188 192
Spiders Araneae 1,453 1,529 130 132
Snails Gastropoda 1,424 1,434 120 117
Scorpions Scorpiones 837 1,035 79 84
Sea anemones Actiniaria 278 0 48 0
Insects Hexapoda 159 423 58 100
Centipede Chilopoda 192 202 8 9
Toad Amphibia 79 1 18 1
Lizards Anguimorpha 34 37 6 6
Fishes Teleostei 32 18 11 6
Mammals Mammalia 8 6 3 1
Hydra Hydroida 4 0 2 0
Mites Acari 6 0 4 0
Starfishes Asteroidea 3 3 1 1
Worms Cerebratulus 3 0 1 0
Medusae Rhopilema 1 0 1 0
Jellyfishes Cubozoa 7 0 4 0
other metazoans - 59 13 25 4
All animals Metazoa 6,580 7,049 706 652

Snake venom proteins - 2,356 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 69%
at transcript level 23.3%
inferred from homology 7.7%
predicted N/A
uncertain N/A

Annotation categories Entries with Number of annotations Coverage
PubMed citations 2,356 2,040 unique 100%
General annotation 2,356 11,958 100%
Function 2,273 2,425 96.5%
Catalytic activity 537 730 22.8%
Subcellular location 0 0 N/A
Toxic dose 0 0 N/A
Sequence annotation 2,356 27,042 100%
Amino acid modifications 2,155 12,063 91.5%
Cross-references 2,356 0 91.3%
EMBL 1,383 0 58.7%
InterPro 2,083 0 88.4%
PDB 244 0 10.4%

100% of reviewed snake venom proteins entries are annotated with at least one keyword .

100% of reviewed snake venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Snail venom proteins - 1,434 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 44.8%
at transcript level 33.8%
inferred from homology 21.3%
predicted N/A
uncertain 0.1%

Annotation categories Entries with Number of annotations Coverage
PubMed citations 1,434 586 unique 100%
General annotation 1,434 6,667 100%
Function 817 833 57%
Catalytic activity 7 7 0.5%
Subcellular location 0 0 N/A
Toxic dose 0 0 N/A
Sequence annotation 1,421 9,320 99.1%
Amino acid modifications 1,231 4,460 85.8%
Cross-references 1,434 0 86.4%
EMBL 875 0 61%
InterPro 863 0 60.2%
PDB 93 0 6.5%
Conoserver 877 0 61.2%

100% of reviewed snail venom proteins entries are annotated with at least one keyword .

99% of reviewed snail venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Scorpion venom proteins - 1,035 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 62.2%
at transcript level 22.8%
inferred from homology 15%
predicted N/A
uncertain N/A

Annotation categories Entries with Number of annotations Coverage
PubMed citations 1,035 789 unique 100%
General annotation 1,035 4,719 100%
Function 923 958 89.2%
Catalytic activity 18 21 1.7%
Subcellular location 0 0 N/A
Toxic dose 0 0 N/A
Sequence annotation 1,031 6,485 99.6%
Amino acid modifications 859 3,113 83%
Cross-references 1,035 0 91.1%
EMBL 558 0 53.9%
InterPro 770 0 74.4%
PDB 112 0 10.8%

100% of reviewed scorpion venom proteins entries are annotated with at least one keyword .

99% of reviewed scorpion venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Spider venom proteins - 1,529 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 47.1%
at transcript level 44%
inferred from homology 9%
predicted N/A
uncertain N/A

Annotation categories Entries with Number of annotations Coverage
PubMed citations 1,529 509 unique 100%
General annotation 1,529 7,673 100%
Function 1,235 1,245 80.8%
Catalytic activity 221 890 14.5%
Subcellular location 0 0 N/A
Toxic dose 0 0 N/A
Sequence annotation 1,520 9,930 99.4%
Amino acid modifications 1,341 4,441 87.7%
Cross-references 1,529 0 97.6%
EMBL 1,071 0 70%
InterPro 1,200 0 78.5%
PDB 88 0 5.8%
ArachnoServer 1,154 0 75.5%

100% of reviewed spider venom proteins entries are annotated with at least one keyword .

99.9% of reviewed spider venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

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