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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01988
    • taxon = Eukaryota
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 64 - 67 aligns to "T-G-x(2)" in entry O19069 (individually applies "Coenzyme A binding")
    • Subsequence at position 90 - 90 aligns to "K" in entry O19069 (individually applies "Coenzyme A")
    • Subsequence at position 143 - 145 aligns to "[IVL]-T-[ED]" in entry O19069 (individually applies "Coenzyme A binding")
    • Subsequence at position 207 - 207 aligns to "Y" in entry O19069 (individually applies "Substrate; shared with subunit beta")
    • Subsequence at position 299 - 299 aligns to "H" in entry O19069 (individually applies "Tele-phosphohistidine intermediate")

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC:6.2.1.4, EC:6.2.1.5)
    Alternative name(s):
    Succinyl-CoA synthetase subunit alpha
    Short name:
    SCS-alpha
  • Recommended name:
    Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial (EC:6.2.1.5)
    Alternative name(s):
    Succinyl-CoA synthetase subunit alpha
    Short name:
    SCS-alpha

Gene namei

  • Name:SUCLG1

Catalytic activityi

  • ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
  • GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.

Functioni

  • Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
  • Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

Pathwayi

  • Pathwayi: tricarboxylic acid cycle

    This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route). This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Subcellular locationi

Sequence similaritiesi

Subunit structurei

  • Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
  • Heterodimer of an alpha and a beta subunit.
  • Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).

Active sitei

  • Tele-phosphohistidine intermediate (to residues corresponding to position 299)

Binding sitei

  • Coenzyme A (to residues corresponding to position 90)
  • Substrate; shared with subunit beta (to residues corresponding to position 207)

Regioni

  • Coenzyme A binding (to residues corresponding to positions 64 - 67)
  • Coenzyme A binding (to residues corresponding to positions 143 - 145)

Keywordsi

GO (Gene Ontology) termsi