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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00206
    • taxon = Eukaryota
    • fragment ≠ the sequence is fragmented
    • Does not match HAMAP signature MF_03129
    • Matches HAMAP signature MF_00206
    • gene location = Plastid
    • fragment ≠ the sequence is fragmented
    • Does not match HAMAP signature MF_03129
    • Matches HAMAP signature MF_00206
    • gene location = Plastid
    • fragment ≠ the sequence is fragmented
    • Does not match HAMAP signature MF_03129
    • taxon ≠ Eukaryota
    • Matches HAMAP signature MF_00206
    • gene location = Plastid
    • fragment ≠ the sequence is fragmented
    • Does not match HAMAP signature MF_03128
    • taxon ≠ Eukaryota
    • Matches HAMAP signature MF_00206
    • gene location = Plastid
    • fragment ≠ the sequence is fragmented
    • taxon ≠ Eukaryota

Special conditions

    • gene location = Plastid; Organellar chromatophore
    • taxon = Apicomplexa
    • gene location ≠ Plastid; Organellar chromatophore
    • taxon ≠ Apicomplexa
    • gene location ≠ Plastid; Organellar chromatophore
    • Subsequence at position 150 - 150 aligns to "C" in entry P32875 (individually applies "Iron-sulfur 1 (4Fe-4S)")
    • Subsequence at position 155 - 155 aligns to "C" in entry P32875 (individually applies "Iron-sulfur 1 (4Fe-4S)")
    • Subsequence at position 161 - 161 aligns to "C" in entry P32875 (individually applies "Iron-sulfur 1 (4Fe-4S)")
    • Subsequence at position 181 - 181 aligns to "C" in entry P32875 (individually applies "Iron-sulfur 2 (4Fe-4S-S-AdoMet)")
    • Subsequence at position 185 - 185 aligns to "C" in entry P32875 (individually applies "Iron-sulfur 2 (4Fe-4S-S-AdoMet)")
    • Subsequence at position 188 - 188 aligns to "C" in entry P32875 (individually applies "Iron-sulfur 2 (4Fe-4S-S-AdoMet)")
    • Predicted signal

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Lipoyl synthase, organellar chromatophore (EC:2.8.1.8)
    Alternative name(s):
    Lipoic acid synthase
    Lipoate synthase
    Short name:
    Lip-syn
    Short name:
    LS
  • Recommended name:
    Lipoyl synthase, apicoplast (EC:2.8.1.8)
    Alternative name(s):
    Lipoate synthase
    Short name:
    Lip-syn
    Short name:
    LS
    Lipoic acid synthase
  • Recommended name:
    Lipoyl synthase, mitochondrial (EC:2.8.1.8)
    Alternative name(s):
    Lipoate synthase
    Short name:
    Lip-syn
    Short name:
    LS
    Lipoic acid synthase

Gene namesi

  • Name:LIAS
  • Name:lipA
  • Name:LIP5
  • Name:Las

Cofactori

  • [4Fe-4S] clusterNote: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathwayi

  • Pathwayi: protein lipoylation via endogenous pathway

    This protein is involved in step 2 of the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]. This subpathway is part of the pathway protein lipoylation via endogenous pathway, which is itself part of Protein modification.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein], the pathway protein lipoylation via endogenous pathway and in Protein modification.

Catalytic activityi

  • Protein N6-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = protein N6-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin.

Functioni

  • Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.

Subcellular locationi

Sequence similaritiesi

Metal bindingi

  • Iron-sulfur 1 (4Fe-4S) (to residues corresponding to position 150)
  • Iron-sulfur 1 (4Fe-4S) (to residues corresponding to position 155)
  • Iron-sulfur 1 (4Fe-4S) (to residues corresponding to position 161)
  • Iron-sulfur 2 (4Fe-4S-S-AdoMet) (to residues corresponding to position 181)
  • Iron-sulfur 2 (4Fe-4S-S-AdoMet) (to residues corresponding to position 185)
  • Iron-sulfur 2 (4Fe-4S-S-AdoMet) (to residues corresponding to position 188)

Chaini

  • @CHAIN_NAME@i (to residues corresponding to positions @TO|+1@i - @CTER@i)

Signal peptidei

  • (to residues corresponding to positions @NTER@i - @TO@i)

Keywordsi

GO (Gene Ontology) termsi