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The annotation and conditions in this rule are derived from the following entries: Q9S5X0 (HPPA_THEMA), Q3AFC6 (HPPA_CARHZ), Q8ZWI8 (HPPA_PYRAE), Q8PYZ8 (HPPA1_METMA)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 495 - 495 aligns to "A" in entry Q9S5X0
    • Subsequence at position 495 - 495 does not align to "A" in entry Q9S5X0
    • Subsequence at position 476 - 476 aligns to "K" in entry Q8ZWI8
    • Subsequence at position 495 - 495 does not align to "A" in entry Q9S5X0
    • Subsequence at position 495 - 495 does not align to "A" in entry Q9S5X0
    • Subsequence at position 476 - 476 does not align to "K" in entry Q8ZWI8
    • Subsequence at position 476 - 476 aligns to "K" in entry Q8ZWI8
    • Subsequence at position 495 - 495 aligns to "A" in entry Q9S5X0
    • Predicted transmembrane

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Putative K(+)-stimulated pyrophosphate-energized sodium pump (EC:3.6.1.1)
    Alternative name(s):
    Membrane-bound sodium-translocating pyrophosphatase
    Pyrophosphate-energized inorganic pyrophosphatase
    Short name:
    Na(+)-PPase
  • Recommended name:
    K(+)-insensitive pyrophosphate-energized proton pump (EC:3.6.1.1)
    Alternative name(s):
    Pyrophosphate-energized inorganic pyrophosphatase
    Short name:
    H(+)-PPase
    Membrane-bound proton-translocating pyrophosphatase
  • Recommended name:
    Pyrophosphate-energized proton pump (EC:3.6.1.1)
    Alternative name(s):
    Pyrophosphate-energized inorganic pyrophosphatase
    Short name:
    H(+)-PPase
    Membrane-bound proton-translocating pyrophosphatase

Gene namei

  • Name:hppA

Subunit structurei

  • Homodimer.

Sequence similaritiesi

Catalytic activityi

  • Diphosphate + H2O = 2 phosphate.

Cofactori

Functioni

  • Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane.
  • Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

Subcellular locationi

Enzyme regulationi

  • Requires K+ for maximal activity.

Transmembranei

  • Helical (to residues corresponding to positions @FROM@i - @TO@i)

Sitei

  • Determinant of potassium independence (to residues corresponding to position 476)
  • Determinant of potassium dependence (to residues corresponding to position 495)

Keywordsi

GO (Gene Ontology) termsi

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